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VOLUME 95 , ISSUE 2E ( March-April, 2021 ) > List of Articles

Original Article

Effect of 3% topical trehalose on the rate of corneal re-epithelialization in patients undergoing photorefractive keratectomy

Alberto Haber, Eduardo J. Polanía-Barón

Keywords : Refractive surgical procedures, Photorefractive keratectomy, Re-epithelialization, Trehalose

Citation Information : Haber A, Polanía-Barón EJ. Effect of 3% topical trehalose on the rate of corneal re-epithelialization in patients undergoing photorefractive keratectomy. 2021; 95 (2E):68-72.

DOI: 10.24875/RMOE.M21000158

License: CC BY-NC-ND 4.0

Published Online: 16-03-2021

Copyright Statement:  Copyright © 2020 Sociedad Mexicana de Oftalmología. Published by Permanyer


Purpose: To study the changes in corneal re-epithelialization rate in patients undergoing surface photorefractive keratectomy by using 3% trehalose. Methods: This is a prospective, randomized, controlled clinical trial. The inclusion criteria were patients older than 18 years, with clinical and topographic criteria for refractive surgery, who agreed to participate in the protocol. Randomization was carried out to assign one eye of each patient to the control group with conventional treatment and the other eye to the experimental group with 3% trehalose plus conventional treatment. The free image processing software Image J was used to quantify the area of de-epithelialization in square millimeters. Results: The average number of epithelialization days was of 2.984 days in the experimental group and of 2.954 days in the control group (not statistically significant; p = 0.1624063). The area of de-epithelialization in the examination prior to reaching 100% epithelialization was of 4.255 mm2 in the experimental group and 3.1762 mm2 in the control group (not statistically significant; p = 0.0899374). Conclusions: Topical instillation of 3% trehalose does not increase the rate of corneal re-epithelialization in patients undergoing photorefractive keratectomy.

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