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VOLUME 95 , ISSUE 1S ( January-February, 2021 ) > List of Articles

ARTÍCULO ORIGINAL

Acortamiento de la longitud telomérica en adultos jóvenes con catarata

Vanesa Rivero-Gutiérrez, Javier Fernández-Mateos, Lourdes de Juan-Marcos, Fernando Cruz-González, Emiliano Hernández-Galilea, Rogelio González-Sarmiento

Keywords : Cataratas, Diabetes, Hipertensión, Longitud telomérica, Polimorfismo, Tabaquismo

Citation Information : Rivero-Gutiérrez V, Fernández-Mateos J, de Juan-Marcos L, Cruz-González F, Hernández-Galilea E, González-Sarmiento R. Acortamiento de la longitud telomérica en adultos jóvenes con catarata. 2021; 95 (1S):1-7.

DOI: 10.24875/RMO.M20000147

License: CC BY-NC-ND 4.0

Published Online: 11-01-2021

Copyright Statement:  Copyright © 2018 Sociedad Mexicana de Oftalmología. Publicado por Permanyer.


Abstract

Objetivo: Se realizó un estudio prospectivo observacional con 205 adultos (102 casos y 103 controles) clasificados en grupos de 55 años y 60 años, con el fin de evaluar la longitud telomérica en pacientes con y sin catarata, y los efectos de los polimorfismos (TERC y TERT) de la telomerasa sobre dicha longitud. Métodos: La longitud telomérica y los polimorfismos de la telomerasa se cuantificaron en leucocitos de sangre periférica por reacción en cadena de la polimerasa. Se utilizaron sondas TaqMan® para genotipificar polimorfismos de telomerasa (TERT 1327C>T y TERC 63G>A). Resultados: Independientemente de la edad, los pacientes con catarata tenían longitudes teloméricas más cortas que los controles (p < 0.01). No se detectó asociación entre el acortamiento de los telómeros y TERC 63G>A en casos ni en controles, y no hubo correlación entre la longitud telomérica en los leucocitos y los factores de riesgo cardiovascular en los pacientes con catarata. Conclusiones: Sin que influyera la edad, los telómeros en leucocitos de sangre periférica de pacientes con catarata fueron más cortos que en aquellos sin catarata. Nuestros hallazgos sugieren que el desarrollo de cataratas está asociado con el envejecimiento de las células de la sangre periférica.

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