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VOLUME 94 , ISSUE 2E ( March-April, 2020 ) > List of Articles

Original Article

Microbial etiology of neonatal conjunctivitis in a hospital in the city of Medellín

Martha L. Gaviria-Bravo, Yenny Llano-Naranjo, Oscar A. Villada-Ochoa

Keywords : Neonatal conjunctivitis, Risk factors, Culture, Bacteria

Citation Information : Gaviria-Bravo ML, Llano-Naranjo Y, Villada-Ochoa OA. Microbial etiology of neonatal conjunctivitis in a hospital in the city of Medellín. 2020; 94 (2E):50-56.

DOI: 10.24875/RMOE.M20000104

License: CC BY-NC-ND 4.0

Published Online: 01-03-2020

Copyright Statement:  Copyright © 2019 Sociedad Mexicana de Oftalmología. Published by Permanyer


Abstract

Objective: To describe the microbial etiology, maternal risk factors and antibiotic sensitivity of neonatal conjunctivitis at San Vicente Hospital Foundation in Medellín since 2012-2018. Methodology: A descriptive, ambispective trial was carried out between January 2012 and November 2018. We reviewed the medical records of patients diagnosed with neonatal bacterial conjunctivitis with positive cultures of conjunctival secretion. Sociodemographic variables of the mother and the neonate, associated risk factors, results of the microbiological isolations, topical and systemic antibiotic therapy and antibiotic sensitivity were recorded. Results: A total of 69 newborns were identified, 65.22% were male, the average age was 15.7 ± 8.3 days. Major etiological agents identified were Staphylococcus epidermidis (n = 20, 28.9%), Staphylococcus aureus (n = 12, 17.3%) and Haemophilus influenzae (9 patients, 13.0%). There were no positive isolates for Chlamydia trachomatis or Neisseria gonorrhoeae. The most common maternal peripartum risk factors were premature rupture of the ovular membranes (n = 16, 21.33%), urinary tract infection (7 cases, 10.1%), preterm birth syndrome (n = 6, 8.00%) and bacterial vaginosis (5 cases, 7.25%). Resistance to oxacillin 26% (n = 18) and tetracyclines 15% (n = 11) was observed in patients with Staphylococcus infection. Conclusion: Over the years, the epidemiology of neonatal conjunctivitis has changed. Nowadays, gonococcal pathogens are not the most common cause of neonatal conjunctivitis. A significant number of patients with methicillin-resistant S. aureus were observed.


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  1. Hammerschlag MR. Chlamydial and Gonococcal Infections in Infants and Children. Clin Infect Dis. 2011;53(suppl_3):S99-102.
  2. Shahid E, Shaikh A, Aziz S, Rehman A. Frequency of Ocular Diseases in Infants at a Tertiary Care Hospital. Korean J Ophthalmol KJO. 2019;33(3):287-93.
  3. Gilbert C, Foster A. Childhood blindness in the context of VISION 2020- -the right to sight. Bull World Health Organ. 2001;79(3):227-32.
  4. Cortés VR, Hernández R. Enfermedad infecciosa neonatal y gérmenes patógenos en un hospital de tercer nivel. (Spanish). Bol Med Hosp Infant Mex. 2006;63:S33-4.
  5. Mohammed A, Ibrahim M, Mustafa A, Ihesiulor U. Maternal risk factors for neonatal conjunctivitis in Aminu Kano Teaching Hospital, Kano, Nigeria. Niger J Basic Clin Sci. 2013;10(2):60.
  6. Krohn MA, Hillier SL, Bell TA, Kronmal RA, Grayston JT. The Bacterial Etiology of Conjunctivitis in Early Infancy. Am J Epidemiol. 1993;138(5):326-32.
  7. Palafox SKV, Jasper S, Tauber, Allyson D, Foster SC. Ophthalmia Neonatorum. J Clin Exp Ophthalmol [Internet]. 2010;2:119el 27 de diciembre de 2010 [citado el 28 de diciembre de 2017];2(1). Disponible en: https://www. omicsonline.org/ophthalmia-neonatorum-2155-9570.1000119.php?aid=1094
  8. Zikic A, Schünemann H, Wi T, Lincetto O, Broutet N, Santesso N. Treatment of Neonatal Chlamydial Conjunctivitis: A Systematic Review and Meta-analysis. J Pediatr Infect Dis Soc. 2018;7(3):e107-15.
  9. Afjeiee SA, Tabatabaei SR, Fallah F, Shiva F, Zanjani NT, Fard AT, et al. A microbiological study of neonatal conjunctivitis in two hospitals in Tehran, Iran. Asian Pac J Trop Dis. 2013;3(6):429-33.
  10. Pak KY, Kim SI, Lee JS. Neonatal Bacterial Conjunctivitis in Korea in the 21st Century. Cornea. 2017;36(4):415-8.
  11. Alexandre I, Cortes N, Justel M, Fernández I, Ortíz de Lejarazu R, Pastor JC. The value of simple microbiological studies for on-site screening of acute neonatal conjunctivitis in Angola. J Ophthalmic Inflamm Infect. 2014;4(1):1.
  12. Kara M, Kıvanç SA, Olcaysü OO, Akova Budak B, Özmen AT, Kıvanç M, et al. The newborn conjunctival flora at the post delivery 24 hours. J Curr Ophthalmol. 2018;30(4):348-52.
  13. Rodríguez Gazquez M de los Á, Correa Munoz E, Ospina Ospina S, Giraldo Jiménez C. Etiología bacteriana de la conjuntivitis neonatal. Metrosalud. Medellín, 1994. Colombia Medica. 1997;28(2):58-61.
  14. Trujillo H, Restrepo C, Correa A, Robledo C, Harry N, Mejía GI. Conjuntivitis por Chlamydia trachomatis en recién nacidos y lactantes. Med UPB. 1989;8(1):27-32.
  15. Schaller UC, Klauss V. Is Credé's prophylaxis for ophthalmia neonatorum still valid? Bull World Health Organ. 2001;79(3):262-3.
  16. Mallika P, Asok T, Faisal H, Aziz S, Tan A, Intan G. Neonatal Conjunctivitis - a Review. Malays Fam Physician Off J Acad Fam Physicians Malays. 2008;3(2):77-81.
  17. Gul SS, Jamal M, Khan N. Ophthalmia neonatorum. J Coll Physicians Surg--Pak JCPSP. 2010;20(9):595-8.
  18. McAnena L, Knowles SJ, Curry A, Cassidy L. Prevalence of gonococcal conjunctivitis in adults and neonates. Eye Lond Engl. julio de 2015;29(7):875-80.
  19. Nsanze H, Dawodu A, Usmani A, Sabarinathan K, Varady E. Ophthalmia neonatorum in the United Arab Emirates. Ann Trop Paediatr. 1996; 16(1):27-32.
  20. Nishida H, Risemberg HM. Silver nitrate ophthalmic solution and chemical conjunctivitis. Pediatrics. 1975;56(3):368-73.
  21. Armstrong JH, Zacarias F, Rein MF. Ophthalmia neonatorum: a chart review. Pediatrics. 1976;57(6):884-92.
  22. Laga M, Nzanze H, Brunham R, Maitha G, D'Costa L, Mati JK, et al. Epidemiology of ophthalmia neonatorum in Kenya. The Lancet. 1986; 328(8516):1145-9.
  23. Kim BL, Choi TH, Lee HB. The Neonatal Conjunctivitis. J Korean Ophthalmol Soc. 1997;38(9):1537-44.
  24. Di SB, Mirta DH, Janer M, Rodríguez MF, Sauka D, Magarinos F, et al. Incidence of Chlamydia trachomatis and other potential pathogens in neonatal conjunctivitis. Int J Infect Dis IJID Off Publ Int Soc Infect Dis. 2001;5(3):139-43.
  25. Rodríguez Gazquez M de los Á, Correa Munoz E, Ospina Ospina S, Giraldo Jiménez C. Etiología bacteriana de la conjuntivitis neonatal. Colomb Médica [Internet]. 1997 [citado el 13 de noviembre de 2017];28(2). Disponible en: http://www.redalyc.org/resumen.oa?id=28328202.
  26. Honkila M, Renko M, Ikäheimo I, Pokka T, Uhari M, Tapiainen T. Aetiology of neonatal conjunctivitis evaluated in a population-based setting. Acta Paediatr Oslo Nor 1992. 2018;107(5):774-9.
  27. Kokou V, Nidain M, Kassoula NB, Kwassi F-A, Meba B, Patrice BK. [Neonatal conjunctivitis in the district of Glidji in Southern Togo: a cross sectional study about 159 new-borns]. Pan Afr Med J. 2016;24:42.
  28. Satpathy G, Behera HS, Ahmed NH. Chlamydial eye infections: Current perspectives. Indian J Ophthalmol. 2017;65(2):97-102.
  29. Tang S, Li M, Chen H, Ping G, Zhang C, Wang S. A chronological study of the bacterial pathogen changes in acute neonatal bacterial conjunctivitis in southern China. BMC Ophthalmol. 2017;17(1):174.
  30. Foster A, Klauss V. Ophthalmia neonatorum in developing countries. N Engl J Med. 1995;332(9):600-1.
  31. Isenberg SJ, Apt L, Wood M. The influence of perinatal infective factors on ophthalmia neonatorum. J Pediatr Ophthalmol Strabismus. 1996; 33(3):185-8.
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